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This will alert our moderators to take action Name Reason for reporting: Foul language Slanderous Inciting hatred against a certain community Others. Thus, these findings have significant implications for future research. Most of the linkage genes revealed by the study lack experimental evidence in context of peri-implantitis-T2DM disease association. In theory, these molecular entities could be valuable as potential targets for individualized gene therapy, risk stratification, and therapy of peri-implantitis in type 2 diabetes.
Further validation of key molecular mechanisms could promote the development of targeted drugs for blocking or aiding their expression and modulating related pathways. Most importantly, the present findings may be considered as hypotheses for future validation experiments and direction for research. As such, bioinformatic data mining of experimental transcriptomes is exploratory and at best considered as a source of well-supported hypotheses. Bioinformatics analysis combining experimental transcriptomic data from T2DM and peri-implantitis revealed potentially shared molecular linkages.
Future studies should explore their roles in context of T2DM-peri-implantitis disease association. Table S1. Common use cases Typos, corrections needed, missing information, abuse, etc. Our promise PeerJ promises to address all issues as quickly and professionally as possible. We thank you in advance for your patience and understanding. You can also choose to receive updates via daily or weekly email digests. If you are following multiple publications then we will send you no more than one email per day or week based on your preferences.
View 2 tweets. Share Twitter Facebook Email. Molecular mechanisms linking peri-implantitis and type 2 diabetes mellitus revealed by transcriptomic analysis. View article. Introduction With the increasing use of dental implants in oral rehabilitation, peri-implant inflammatory diseases have risen in incidence and comprise a significant clinical challenge.
Cross-talk gene analysis Protein—protein interaction networks for peri-implantitis and T2DM were merged to construct a global network. Functional enrichment analysis Differentially expressed genes in peri-implantitis were mainly involved in the BPs of neutrophil activation, neutrophil mediated immunity, antigen processing and presentation of peptide antigen via MHC class I, and positive regulation of protein catabolic process Fig.
Download full-size image. DOI: Table 1: The functions of genes identified in the pathogenesis of T2DM and peri-implantitis, respectively. The top 30 BP enriched in genes related to type 2 diabetes mellitus. All the pathways enriched in DEGs related to peri-implantitis. All the pathways enriched in genes related to type 2 diabetes mellitus.
The comparison between different classes in peri-implantitis a and type II diabetes b. The horizontal axis represents the different class, and the vertical axis represents the comscore corresponding to the class. The letter a-e shows the difference b. Tables S1-S3. Table S2. Table S3. Three leader genes shared in two selected significant classes.
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